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Why was Michael Smith awarded Noble Prize in 1993?

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Why was Michael Smith awarded Noble Prize in1993?Name: Michael Smith. 
Country: United States.
Date of Birth: 26 April 1932.
Died: 4 October 2000.
The subject of Study: Site-directed mutagenesis.
Noble Prize Year: Nobel Prize for Chemistry in 1993 for their research on developing site-directed mutagenesis.
Fields: Chemistry.

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